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The common TMEM173 HAQ, AQ alleles rescue CD4 T cell death, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice
STING activation induces lymphocyte cell death that is independent of type I IFNs. The in vivo significance and mechanism of STING-mediated cell death is unclear. Using STING knock-in mice, we found that lymphocytes from the HAQ, AQ, and Q293 mice are resistant to STING-mediated cell death ex vivo,...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602033/ https://www.ncbi.nlm.nih.gov/pubmed/37886547 http://dx.doi.org/10.1101/2023.10.05.561109 |