Genetics of NLRP3 suggests lack of involvement and inefficient druggability in Parkinson’s disease

Activation of the NLRP3-inflammasome has been proposed to play a role in Parkinson’s disease pathogenesis based on in vitro and in vivo studies. Currently, clinical trials targeting the NLRP3 pathway in Parkinson’s disease are at early stages. However, the evidence supporting NLRP3’s involvement in...

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Detalles Bibliográficos
Autores principales: Senkevich, Konstantin, Liu, Lang, Alvarado, Chelsea X., Leonard, Hampton L., Nalls, Mike A., Gan-Or, Ziv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602039/
https://www.ncbi.nlm.nih.gov/pubmed/37886468
http://dx.doi.org/10.1101/2023.09.20.23295790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602039/
https://www.ncbi.nlm.nih.gov/pubmed/37886468
http://dx.doi.org/10.1101/2023.09.20.23295790

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