Deactivation of ligand-receptor interactions enhancing lymphocyte infiltration drives melanoma resistance to Immune Checkpoint Blockade

Immune checkpoint blockade (ICB) is a promising cancer therapy; however, resistance often develops. To learn more about ICB resistance mechanisms, we developed IRIS (Immunotherapy Resistance cell-cell Interaction Scanner), a machine learning model aimed at identifying candidate ligand-receptor inter...

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Detalles Bibliográficos
Autores principales: Sahni, Sahil, Wang, Binbin, Wu, Di, Dhruba, Saugato Rahman, Nagy, Matthew, Patkar, Sushant, Ferreira, Ingrid, Wang, Kun, Ruppin, Eytan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602042/
https://www.ncbi.nlm.nih.gov/pubmed/37886558
http://dx.doi.org/10.1101/2023.09.20.558683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602042/
https://www.ncbi.nlm.nih.gov/pubmed/37886558
http://dx.doi.org/10.1101/2023.09.20.558683

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