Cargando…

Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity

We identified genetic subtypes of type 2 diabetes (T2D) by analyzing genetic data from diverse groups, including non-European populations. We implemented soft clustering with 650 T2D-associated genetic variants, capturing known and novel T2D subtypes with distinct cardiometabolic trait associations....

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Kirk, Deutsch, Aaron J., McGrail, Carolyn, Kim, Hyunkyung, Hsu, Sarah, Mandla, Ravi, Schroeder, Philip H., Westerman, Kenneth E., Szczerbinski, Lukasz, Majarian, Timothy D., Kaur, Varinderpal, Williamson, Alice, Claussnitzer, Melina, Florez, Jose C., Manning, Alisa K., Mercader, Josep M., Gaulton, Kyle J., Udler, Miriam S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602111/
https://www.ncbi.nlm.nih.gov/pubmed/37886436
http://dx.doi.org/10.21203/rs.3.rs-3399145/v1