A Scan of Pleiotropic Immune Mediated Disease Genes Identifies Novel Determinants of Baseline FVIII Inhibitor Status in Hemophilia-A

Hemophilia-A (HA) is caused by heterogeneous loss-of-function factor (F)VIII gene (F8)-mutations and deficiencies in plasma-FVIII-activity that impair intrinsic-pathway-mediated coagulation-amplification. The standard-of-care for severe-HA-patients is regular infusions of therapeutic-FVIII-proteins...

Descripción completa

Detalles Bibliográficos
Autores principales: Howard, Tom, Almieda, Marcio, Diego, Vincent, Viel, Kevin, Luu, Bernadette, Haack, Karin, Raja, Rajalingam, Ameri, Afshin, Chitlur, Meera, Rydz, Natalia, Lillicrap, David, Watts, Raymond, Kessler, Craig, Ramsey, Christopher, Dinh, Long, Kim, Benjamin, Powell, Jerry, Peralta, Juan, Bouls, Ruayda, Abraham, Shirley, Shen, Yu-Min, Murillo, Carlos, Mead, Henry, Lehmann, Paul, Fine, Eli, Escobar, Miguel, Kumar, Satish, Williams-Blangero, Sarah, Kasper, Carol, Almasy, Laura, Cole, Shelley, Blangero, John, Konkle, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602130/
https://www.ncbi.nlm.nih.gov/pubmed/37886476
http://dx.doi.org/10.21203/rs.3.rs-3371095/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602130/
https://www.ncbi.nlm.nih.gov/pubmed/37886476
http://dx.doi.org/10.21203/rs.3.rs-3371095/v1

Ejemplares similares