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Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and gen...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Journal Experts
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602152/ https://www.ncbi.nlm.nih.gov/pubmed/37886563 http://dx.doi.org/10.21203/rs.3.rs-3258813/v1 |
| _version_ | 1785126336480673792 |
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| author | Kelsoe, John Ou, Anna Rosenthal, Sara Adli, Mazda Akiyama, Kazufumi Akula, Nirmala Alda, Martin Amare, Azmeraw T. Ardau, Raffaella Arias, Bárbara Aubry, Jean-Michel Backlund, Lena Banzato, Claudio Bauer, Michael Baune, Bernhard Bellivier, Frank Benabarre, Antonio Bengesser, Susanne Abesh, Bhattacharjee Biernacka, Joanna Bui, Elise Cervantes, Pablo Chen, Guo-Bo Chen, Hsi-Chung Chillotti, Caterina Cichon, Sven Clark, Scott Colom, Francesc Cousins, David Cruceanu, Cristiana Czerski, Piotr Dantas, Clarissa Dayer, Alexandre Degenhardt, Franziska DePaulo, J. Raymond Etain, Bruno Falkai, Peter Fellendorf, Frederike Ferensztajn-Rochowiak, Ewa Forstner, Andreas J. Frisen, Louise Frye, Mark Fullerton, Janice Gard, Sebastien Garnham, Julie Goes, Fernando Grigoroiu-Serbanescu, Maria Grof, Paul Gruber, Oliver Hashimoto, Ryota Hauser, Joanna Heilbronner, Urs Herms, Stefan Hoffmann, Per Hofmann, Andrea Hou, Liping Jamain, Stéphane Jiménez, Esther Kahn, Jean-Pierre Kassem, Layla Kato, Tadafumi Kittel-Schneider, Sarah König, Barbara kuo, Po-Hsiu Kusumi, Ichiro Dalkner, Nina Laje, Gonzalo Landén, Mikael Lavebratt, Catharina Leboyer, Marion Leckband, Susan Jaramillo, Carlos López MacQueen, Glenda Maj, Mario Manchia, Mirko Marie-Claire, Cynthia Martinsson, Lina Mattheisen, Manuel McCarthy, Michael McElroy, Susan McMahon, Francis Mitchell, Philip Mitjans, Marina Mondimore, Francis Monteleone, Palmiero Nievergelt, Caroline Nöthen, Markus Novak, Tomas Osby, Urban Ozaki, Norio Papiol, Sergi Perlis, Roy Pfennig, Andrea Potash, James Reich-Erkelenz, Daniela Reif, Andreas Reininghaus, Eva Rietschel, Marcella Rouleau, Guy Rybakowski, Janusz K. Schalling, Martin Schofield, Peter Schubert, Klaus Oliver Schulze, Thomas SCHWEIZER, BARBARA Seemüller, Florian Severino, Giovanni Shekhtman, Tatyana Shilling, Paul Shimoda, Kazutaka Simhandl, Christian slaney, claire Squassina, Alessio Stamm, Thomas Stopkova, Pavla Tighe, Sarah Tortorella, Alfonso Turecki, Gustavo Vieta, Eduard Volkert, Julia Witt, Stephanie Wray, Naomi Wright, Adam Young, Trevor Zandi, Peter Zompo, Maria Del |
| author_facet | Kelsoe, John Ou, Anna Rosenthal, Sara Adli, Mazda Akiyama, Kazufumi Akula, Nirmala Alda, Martin Amare, Azmeraw T. Ardau, Raffaella Arias, Bárbara Aubry, Jean-Michel Backlund, Lena Banzato, Claudio Bauer, Michael Baune, Bernhard Bellivier, Frank Benabarre, Antonio Bengesser, Susanne Abesh, Bhattacharjee Biernacka, Joanna Bui, Elise Cervantes, Pablo Chen, Guo-Bo Chen, Hsi-Chung Chillotti, Caterina Cichon, Sven Clark, Scott Colom, Francesc Cousins, David Cruceanu, Cristiana Czerski, Piotr Dantas, Clarissa Dayer, Alexandre Degenhardt, Franziska DePaulo, J. Raymond Etain, Bruno Falkai, Peter Fellendorf, Frederike Ferensztajn-Rochowiak, Ewa Forstner, Andreas J. Frisen, Louise Frye, Mark Fullerton, Janice Gard, Sebastien Garnham, Julie Goes, Fernando Grigoroiu-Serbanescu, Maria Grof, Paul Gruber, Oliver Hashimoto, Ryota Hauser, Joanna Heilbronner, Urs Herms, Stefan Hoffmann, Per Hofmann, Andrea Hou, Liping Jamain, Stéphane Jiménez, Esther Kahn, Jean-Pierre Kassem, Layla Kato, Tadafumi Kittel-Schneider, Sarah König, Barbara kuo, Po-Hsiu Kusumi, Ichiro Dalkner, Nina Laje, Gonzalo Landén, Mikael Lavebratt, Catharina Leboyer, Marion Leckband, Susan Jaramillo, Carlos López MacQueen, Glenda Maj, Mario Manchia, Mirko Marie-Claire, Cynthia Martinsson, Lina Mattheisen, Manuel McCarthy, Michael McElroy, Susan McMahon, Francis Mitchell, Philip Mitjans, Marina Mondimore, Francis Monteleone, Palmiero Nievergelt, Caroline Nöthen, Markus Novak, Tomas Osby, Urban Ozaki, Norio Papiol, Sergi Perlis, Roy Pfennig, Andrea Potash, James Reich-Erkelenz, Daniela Reif, Andreas Reininghaus, Eva Rietschel, Marcella Rouleau, Guy Rybakowski, Janusz K. Schalling, Martin Schofield, Peter Schubert, Klaus Oliver Schulze, Thomas SCHWEIZER, BARBARA Seemüller, Florian Severino, Giovanni Shekhtman, Tatyana Shilling, Paul Shimoda, Kazutaka Simhandl, Christian slaney, claire Squassina, Alessio Stamm, Thomas Stopkova, Pavla Tighe, Sarah Tortorella, Alfonso Turecki, Gustavo Vieta, Eduard Volkert, Julia Witt, Stephanie Wray, Naomi Wright, Adam Young, Trevor Zandi, Peter Zompo, Maria Del |
| author_sort | Kelsoe, John |
| collection | PubMed |
| description | Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2,039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD. |
| format | Online Article Text |
| id | pubmed-10602152 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | American Journal Experts |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-106021522023-10-27 Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study Kelsoe, John Ou, Anna Rosenthal, Sara Adli, Mazda Akiyama, Kazufumi Akula, Nirmala Alda, Martin Amare, Azmeraw T. Ardau, Raffaella Arias, Bárbara Aubry, Jean-Michel Backlund, Lena Banzato, Claudio Bauer, Michael Baune, Bernhard Bellivier, Frank Benabarre, Antonio Bengesser, Susanne Abesh, Bhattacharjee Biernacka, Joanna Bui, Elise Cervantes, Pablo Chen, Guo-Bo Chen, Hsi-Chung Chillotti, Caterina Cichon, Sven Clark, Scott Colom, Francesc Cousins, David Cruceanu, Cristiana Czerski, Piotr Dantas, Clarissa Dayer, Alexandre Degenhardt, Franziska DePaulo, J. Raymond Etain, Bruno Falkai, Peter Fellendorf, Frederike Ferensztajn-Rochowiak, Ewa Forstner, Andreas J. Frisen, Louise Frye, Mark Fullerton, Janice Gard, Sebastien Garnham, Julie Goes, Fernando Grigoroiu-Serbanescu, Maria Grof, Paul Gruber, Oliver Hashimoto, Ryota Hauser, Joanna Heilbronner, Urs Herms, Stefan Hoffmann, Per Hofmann, Andrea Hou, Liping Jamain, Stéphane Jiménez, Esther Kahn, Jean-Pierre Kassem, Layla Kato, Tadafumi Kittel-Schneider, Sarah König, Barbara kuo, Po-Hsiu Kusumi, Ichiro Dalkner, Nina Laje, Gonzalo Landén, Mikael Lavebratt, Catharina Leboyer, Marion Leckband, Susan Jaramillo, Carlos López MacQueen, Glenda Maj, Mario Manchia, Mirko Marie-Claire, Cynthia Martinsson, Lina Mattheisen, Manuel McCarthy, Michael McElroy, Susan McMahon, Francis Mitchell, Philip Mitjans, Marina Mondimore, Francis Monteleone, Palmiero Nievergelt, Caroline Nöthen, Markus Novak, Tomas Osby, Urban Ozaki, Norio Papiol, Sergi Perlis, Roy Pfennig, Andrea Potash, James Reich-Erkelenz, Daniela Reif, Andreas Reininghaus, Eva Rietschel, Marcella Rouleau, Guy Rybakowski, Janusz K. Schalling, Martin Schofield, Peter Schubert, Klaus Oliver Schulze, Thomas SCHWEIZER, BARBARA Seemüller, Florian Severino, Giovanni Shekhtman, Tatyana Shilling, Paul Shimoda, Kazutaka Simhandl, Christian slaney, claire Squassina, Alessio Stamm, Thomas Stopkova, Pavla Tighe, Sarah Tortorella, Alfonso Turecki, Gustavo Vieta, Eduard Volkert, Julia Witt, Stephanie Wray, Naomi Wright, Adam Young, Trevor Zandi, Peter Zompo, Maria Del Res Sq Article Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2,039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD. American Journal Experts 2023-10-03 /pmc/articles/PMC10602152/ /pubmed/37886563 http://dx.doi.org/10.21203/rs.3.rs-3258813/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. https://creativecommons.org/licenses/by/4.0/License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License (https://creativecommons.org/licenses/by/4.0/) |
| spellingShingle | Article Kelsoe, John Ou, Anna Rosenthal, Sara Adli, Mazda Akiyama, Kazufumi Akula, Nirmala Alda, Martin Amare, Azmeraw T. Ardau, Raffaella Arias, Bárbara Aubry, Jean-Michel Backlund, Lena Banzato, Claudio Bauer, Michael Baune, Bernhard Bellivier, Frank Benabarre, Antonio Bengesser, Susanne Abesh, Bhattacharjee Biernacka, Joanna Bui, Elise Cervantes, Pablo Chen, Guo-Bo Chen, Hsi-Chung Chillotti, Caterina Cichon, Sven Clark, Scott Colom, Francesc Cousins, David Cruceanu, Cristiana Czerski, Piotr Dantas, Clarissa Dayer, Alexandre Degenhardt, Franziska DePaulo, J. Raymond Etain, Bruno Falkai, Peter Fellendorf, Frederike Ferensztajn-Rochowiak, Ewa Forstner, Andreas J. Frisen, Louise Frye, Mark Fullerton, Janice Gard, Sebastien Garnham, Julie Goes, Fernando Grigoroiu-Serbanescu, Maria Grof, Paul Gruber, Oliver Hashimoto, Ryota Hauser, Joanna Heilbronner, Urs Herms, Stefan Hoffmann, Per Hofmann, Andrea Hou, Liping Jamain, Stéphane Jiménez, Esther Kahn, Jean-Pierre Kassem, Layla Kato, Tadafumi Kittel-Schneider, Sarah König, Barbara kuo, Po-Hsiu Kusumi, Ichiro Dalkner, Nina Laje, Gonzalo Landén, Mikael Lavebratt, Catharina Leboyer, Marion Leckband, Susan Jaramillo, Carlos López MacQueen, Glenda Maj, Mario Manchia, Mirko Marie-Claire, Cynthia Martinsson, Lina Mattheisen, Manuel McCarthy, Michael McElroy, Susan McMahon, Francis Mitchell, Philip Mitjans, Marina Mondimore, Francis Monteleone, Palmiero Nievergelt, Caroline Nöthen, Markus Novak, Tomas Osby, Urban Ozaki, Norio Papiol, Sergi Perlis, Roy Pfennig, Andrea Potash, James Reich-Erkelenz, Daniela Reif, Andreas Reininghaus, Eva Rietschel, Marcella Rouleau, Guy Rybakowski, Janusz K. Schalling, Martin Schofield, Peter Schubert, Klaus Oliver Schulze, Thomas SCHWEIZER, BARBARA Seemüller, Florian Severino, Giovanni Shekhtman, Tatyana Shilling, Paul Shimoda, Kazutaka Simhandl, Christian slaney, claire Squassina, Alessio Stamm, Thomas Stopkova, Pavla Tighe, Sarah Tortorella, Alfonso Turecki, Gustavo Vieta, Eduard Volkert, Julia Witt, Stephanie Wray, Naomi Wright, Adam Young, Trevor Zandi, Peter Zompo, Maria Del Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study |
| title | Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study |
| title_full | Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study |
| title_fullStr | Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study |
| title_full_unstemmed | Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study |
| title_short | Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study |
| title_sort | lithium response in bipolar disorder is associated with focal adhesion and pi3k-akt networks: a multi-omics replication study |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602152/ https://www.ncbi.nlm.nih.gov/pubmed/37886563 http://dx.doi.org/10.21203/rs.3.rs-3258813/v1 |
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schulzethomas lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT schweizerbarbara lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT seemullerflorian lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT severinogiovanni lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT shekhtmantatyana lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT shillingpaul lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT shimodakazutaka lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT simhandlchristian lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT slaneyclaire lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT squassinaalessio lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT stammthomas lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT stopkovapavla lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT tighesarah lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT tortorellaalfonso lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT tureckigustavo lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT vietaeduard lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT volkertjulia lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT wittstephanie lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT wraynaomi lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT wrightadam lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT youngtrevor lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT zandipeter lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy AT zompomariadel lithiumresponseinbipolardisorderisassociatedwithfocaladhesionandpi3kaktnetworksamultiomicsreplicationstudy |