NK Receptors Replace CD28 As the Dominant Source of Signal 2 for Cognate Recognition of Cancer Cells by TAA-specific Effector CD8(+) T Cells

CD28-driven “signal 2” is critical for naïve CD8(+) T cell responses to dendritic cell (DC)-presented weak antigens, including non-mutated tumor-associated antigens (TAAs). However, it is unclear how DC-primed cytotoxic T lymphocytes (CTLs) respond to the same TAAs presented by cancer cells which la...

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Detalles Bibliográficos
Autores principales: Dong, Bowen, Obermajer, Nataša, Tsuji, Takemasa, Matsuzaki, Junko, Bonura, Cindy, Withers, Henry, Long, Mark, Chavel, Colin, Olejniczak, Scott H., Minderman, Hans, Edwards, Robert P., Storkus, Walter J., Romero, Pedro, Kalinski, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602189/
https://www.ncbi.nlm.nih.gov/pubmed/37886562
http://dx.doi.org/10.21203/rs.3.rs-3399211/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602189/
https://www.ncbi.nlm.nih.gov/pubmed/37886562
http://dx.doi.org/10.21203/rs.3.rs-3399211/v1

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