Coordination between aminoacylation and editing to protect against proteotoxicity

Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that ligate amino acids to tRNAs, and often require editing to ensure accurate protein synthesis. Recessive mutations in aaRSs cause various neurological disorders in humans, yet the underlying mechanism remains poorly understood. Pathogenic a...

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Detalles Bibliográficos
Autores principales: Zhang, Hong, Murphy, Parker, Yu, Jason, Lee, Sukyeong, Tsai, Francis T F, van Hoof, Ambro, Ling, Jiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602869/
https://www.ncbi.nlm.nih.gov/pubmed/37742077
http://dx.doi.org/10.1093/nar/gkad778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602869/
https://www.ncbi.nlm.nih.gov/pubmed/37742077
http://dx.doi.org/10.1093/nar/gkad778

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