Sustained pigmentation causes DNA damage and invokes translesion polymerase Polκ for repair in melanocytes

Melanin protects skin cells from ultraviolet radiation-induced DNA damage. However, intermediates of eumelanin are highly reactive quinones that are potentially genotoxic. In this study, we systematically investigate the effect of sustained elevation of melanogenesis and map the consequent cellular...

Descripción completa

Detalles Bibliográficos
Autores principales: Ghazi, Madeeha, Khanna, Shivangi, Subramaniam, Yogaspoorthi, Rengaraju, Jeyashri, Sultan, Farina, Gupta, Iti, Sharma, Kanupriya, Chandna, Sudhir, Gokhale, Rajesh S, Natarajan, Vivek T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602914/
https://www.ncbi.nlm.nih.gov/pubmed/37697436
http://dx.doi.org/10.1093/nar/gkad704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602914/
https://www.ncbi.nlm.nih.gov/pubmed/37697436
http://dx.doi.org/10.1093/nar/gkad704

Ejemplares similares