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Watching ion-driven kinetics of ribozyme folding and misfolding caused by energetic and topological frustration one molecule at a time

Folding of ribozymes into well-defined tertiary structures usually requires divalent cations. How Mg(2+) ions direct the folding kinetics has been a long-standing unsolved problem because experiments cannot detect the positions and dynamics of ions. To address this problem, we used molecular simulat...

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Detalles Bibliográficos
Autores principales: Hori, Naoto, Thirumalai, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602927/
https://www.ncbi.nlm.nih.gov/pubmed/37758176
http://dx.doi.org/10.1093/nar/gkad755