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Watching ion-driven kinetics of ribozyme folding and misfolding caused by energetic and topological frustration one molecule at a time
Folding of ribozymes into well-defined tertiary structures usually requires divalent cations. How Mg(2+) ions direct the folding kinetics has been a long-standing unsolved problem because experiments cannot detect the positions and dynamics of ions. To address this problem, we used molecular simulat...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602927/ https://www.ncbi.nlm.nih.gov/pubmed/37758176 http://dx.doi.org/10.1093/nar/gkad755 |