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CNS tumor stroma transcriptomics identify perivascular fibroblasts as predictors of immunotherapy resistance in glioblastoma patients

Excessive deposition of extracellular matrix (ECM) is a hallmark of solid tumors; however, it remains poorly understood which cellular and molecular components contribute to the formation of ECM stroma in central nervous system (CNS) tumors. Here, we undertake a pan-CNS analysis of retrospective gen...

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Detalles Bibliográficos
Autores principales: Zarodniuk, Maksym, Steele, Alexander, Lu, Xin, Li, Jun, Datta, Meenal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603041/
https://www.ncbi.nlm.nih.gov/pubmed/37884531
http://dx.doi.org/10.1038/s41525-023-00381-w