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Scribble deficiency mediates colon inflammation by inhibiting autophagy-dependent oxidative stress elimination

Scribble is a master scaffold protein in apical-basal polarity. Current knowledge about the biological function of Scribble in colonic epithelial plasticity/regeneration during intestinal inflammation is limited. Here, we showed that the level of Scribble is decreased in inflammatory bowel disease (...

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Detalles Bibliográficos
Autores principales: Sun, Xia, Lu, Liying, Wang, Kai, Song, Lele, Jiao, Jiazheng, Wu, Yanjun, Wang, Xinyu, Song, Yanan, Zhan, Lixing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603050/
https://www.ncbi.nlm.nih.gov/pubmed/37884590
http://dx.doi.org/10.1038/s41598-023-45176-2