Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1

Poly(ADP-ribose) polymerase (PARP) inhibitors are used in the clinic to treat BRCA-deficient breast, ovarian and prostate cancers. As their efficacy is potentiated by loss of the nucleotide salvage factor DNPH1 there is considerable interest in the development of highly specific small molecule DNPH1...

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Detalles Bibliográficos
Autores principales: Rzechorzek, Neil J., Kunzelmann, Simone, Purkiss, Andrew G., Silva Dos Santos, Mariana, MacRae, James I., Taylor, Ian A., Fugger, Kasper, West, Stephen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603095/
https://www.ncbi.nlm.nih.gov/pubmed/37884503
http://dx.doi.org/10.1038/s41467-023-42544-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603095/
https://www.ncbi.nlm.nih.gov/pubmed/37884503
http://dx.doi.org/10.1038/s41467-023-42544-4

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