Genetic interactions between polycystin-1 and Wwtr1 in osteoblasts define a novel mechanosensing mechanism regulating bone formation in mice

Molecular mechanisms transducing physical forces in the bone microenvironment to regulate bone mass are poorly understood. Here, we used mouse genetics, mechanical loading, and pharmacological approaches to test the possibility that polycystin-1 and Wwtr1 have interdependent mechanosensing functions...

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Detalles Bibliográficos
Autores principales: Xiao, Zhousheng, Cao, Li, Smith, Micholas Dean, Li, Hanxuan, Li, Wei, Smith, Jeremy C., Quarles, Leigh Darryl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603112/
https://www.ncbi.nlm.nih.gov/pubmed/37884491
http://dx.doi.org/10.1038/s41413-023-00295-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603112/
https://www.ncbi.nlm.nih.gov/pubmed/37884491
http://dx.doi.org/10.1038/s41413-023-00295-4

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