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Xrcc5/KU80 is not required for the survival or activation of prophase-arrested oocytes in primordial follicles
INTRODUCTION: The non-growing, meiotically-arrested oocytes housed within primordial follicles are exquisitely sensitive to genotoxic insults from endogenous and exogenous sources. Even a single DNA double-strand break (DSB) can trigger oocyte apoptosis, which can lead to accelerated depletion of th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603181/ https://www.ncbi.nlm.nih.gov/pubmed/37900135 http://dx.doi.org/10.3389/fendo.2023.1268009 |