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Xrcc5/KU80 is not required for the survival or activation of prophase-arrested oocytes in primordial follicles

INTRODUCTION: The non-growing, meiotically-arrested oocytes housed within primordial follicles are exquisitely sensitive to genotoxic insults from endogenous and exogenous sources. Even a single DNA double-strand break (DSB) can trigger oocyte apoptosis, which can lead to accelerated depletion of th...

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Detalles Bibliográficos
Autores principales:	Ratnayaka-Gamage, Natasha D., Alesi, Lauren R., Zerafa, Nadeen, Stringer, Jessica M., Hutt, Karla J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603181/ https://www.ncbi.nlm.nih.gov/pubmed/37900135 http://dx.doi.org/10.3389/fendo.2023.1268009

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