Cargando…

Addressing Acid-Catalyzed Deamidation and the Solubility of Hydrophobic Peptides in Multi-Attribute Method Workflows

[Image: see text] Recently, we introduced an optimized and automated Multi-Attribute Method (MAM) workflow, which (a) significantly reduces the number of missed cleavages using an automated two-step digestion procedure and (b) dramatically reduces chromatographic peak tailing and carryover of hydrop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kristensen, Dan B., Ørgaard, Martin, Sloth, Trine M., Comamala, Gerard, Jensen, Pernille F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603607/ https://www.ncbi.nlm.nih.gov/pubmed/37824441 http://dx.doi.org/10.1021/acs.analchem.3c02609

Ejemplares similares

Optimized Multi-Attribute Method Workflow Addressing Missed Cleavages and Chromatographic Tailing/Carry-Over of Hydrophobic Peptides
por: Kristensen, Dan B., et al.
Publicado: (2022)

Inter-laboratory study of an optimised peptide mapping workflow using automated trypsin digestion for monitoring monoclonal antibody product quality attributes
por: Millán-Martín, Silvia, et al.
Publicado: (2020)

Glycolic Acid-Catalyzed Deamidation of Asparagine Residues in Degrading PLGA Matrices: A Computational Study
por: Manabe, Noriyoshi, et al.
Publicado: (2015)

Coeliac disease in infants: antibodies to deamidated gliadin peptide come first!
por: Arigliani, Michele, et al.
Publicado: (2017)

Allergenicity of Deamidated and/or Peptide-Bond-Hydrolyzed Wheat Gliadin by Transdermal Administration
por: Abe, Ryosuke, et al.
Publicado: (2020)

Enhancing Solubility and Reducing Thermal Aggregation in Pea Proteins through Protein Glutaminase-Mediated Deamidation
por: Luo, Lijuan, et al.
Publicado: (2023)

Prevalence of Anti-deamidated Gliadin Peptide Antibodies in Asian Patients With Irritable Bowel Syndrome
por: Lu, Wei, et al.
Publicado: (2014)

Glutamine deamidation does not increase the immunogenicity of C-peptide in people with type 1 diabetes
por: Foster, Abby, et al.
Publicado: (2022)

Enzyme Catalyzed Copolymerization of Lignosulfonates for Hydrophobic Coatings
por: Mayr, Sebastian A., et al.
Publicado: (2021)

Characterization of Asparagine Deamidation in Immunodominant Myelin Oligodendrocyte Glycoprotein Peptide Potential Immunotherapy for the Treatment of Multiple Sclerosis
por: Androutsou, Maria-Eleni, et al.
Publicado: (2020)

Isolated positive deamidated gliadin peptide‐IgG has limited diagnostic utility in coeliac disease
por: Vootukuru, Nikil, et al.
Publicado: (2022)

Deamidation alters interactions of β-crystallins in hetero-oligomers
por: Takata, Takumi, et al.
Publicado: (2009)

Identification of allergens and epitopes involved in allergy to deamidated gluten
por: Denery, S, et al.
Publicado: (2013)

Implications of Metal Binding and Asparagine Deamidation for Amyloid Formation
por: Sadakane, Yutaka, et al.
Publicado: (2018)

Computational Studies on the Nonenzymatic Deamidation Mechanisms of Glutamine Residues
por: Kato, Koichi, et al.
Publicado: (2019)

Ceruloplasmin Deamidation in Neurodegeneration: From Loss to Gain of Function
por: Zanardi, Alan, et al.
Publicado: (2021)

Changes in Non-Deamidated versus Deamidated Epitope Targeting and Disease Prediction during the Antibody Response to Gliadin and Transglutaminase of Infants at Risk for Celiac Disease
por: Diós, Ádám, et al.
Publicado: (2022)

Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules
por: Choudhary, Sonam, et al.
Publicado: (2017)

Rendering hydrophobic nanoclusters water-soluble and biocompatible
por: Kang, Xi, et al.
Publicado: (2020)

Sequence and Solution Effects on the Prevalence of d-Isomers Produced by Deamidation
por: Riggs, Dylan L., et al.
Publicado: (2017)

Studies on the Proteome of Human Hair - Identification of Histones and Deamidated Keratins
por: Adav, Sunil S., et al.
Publicado: (2018)

Deamidation and isomerization liability analysis of 131 clinical-stage antibodies
por: Lu, Xiaojun, et al.
Publicado: (2018)

Structure Based Prediction of Asparagine Deamidation Propensity in Monoclonal Antibodies
por: Yan, Qingrong, et al.
Publicado: (2018)

Deamidated Human Triosephosphate Isomerase is a Promising Druggable Target
por: Enríquez-Flores, Sergio, et al.
Publicado: (2020)

Engineering an anti-CD52 antibody for enhanced deamidation stability
por: Qiu, Huawei, et al.
Publicado: (2019)

NEDD8 Deamidation Inhibits Cullin RING Ligase Dynamics
por: Mohanty, Priyesh, et al.
Publicado: (2021)

Deciphering deamidation and isomerization in therapeutic proteins: Effect of neighboring residue
por: Irudayanathan, Flaviyan Jerome, et al.
Publicado: (2022)

Pasteurella multocida Toxin Activates Various Heterotrimeric G Proteins by Deamidation
por: Orth, Joachim H. C., et al.
Publicado: (2010)

Control of Cellular Bcl-x(L) Levels by Deamidation-Regulated Degradation
por: Dho, So Hee, et al.
Publicado: (2013)

Application of Deamidated Gliadin Antibodies in the Follow-Up of Treated Celiac Disease
por: de Chaisemartin, Luc, et al.
Publicado: (2015)

Deamidation Reactions of Asparagine- and Glutamine-Containing Dipeptides Investigated by Ion Spectroscopy
por: Kempkes, Lisanne J. M., et al.
Publicado: (2016)

Protein asparagine deamidation prediction based on structures with machine learning methods
por: Jia, Lei, et al.
Publicado: (2017)

Machine Learning Enables Accurate Prediction of Asparagine Deamidation Probability and Rate
por: Delmar, Jared A., et al.
Publicado: (2020)

Machine Learning Enables Accurate Prediction of Asparagine Deamidation Probability and Rate
por: Delmar, Jared A., et al.
Publicado: (2019)

Differential T cell immune responses to deamidated adeno-associated virus vector
por: Bing, So Jin, et al.
Publicado: (2022)

Deamidation-related blood biomarkers show promise for early diagnostics of neurodegeneration
por: Wang, Jijing, et al.
Publicado: (2022)

Characterization of N-Terminal Asparagine Deamidation and Clipping of a Monoclonal Antibody
por: Zhen, Jing, et al.
Publicado: (2023)

Conformational Control of Fast Asparagine Deamidation in a Norovirus Capsid Protein
por: Creutznacher, Robert, et al.
Publicado: (2023)

Molecular Modeling of the Deamidation Reaction in Solution: A Theoretical–Computational Study
por: De Sciscio, Maria Laura, et al.
Publicado: (2023)

Use of content management systems to address nursing workflow
por: Ang, Raymund John
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_6lciqlgvdd6in6d6i3opcv52m1