Reactive Oxygen Species-Dependent Activation of EGFR/Akt/p38 Mitogen-Activated Protein Kinase and JNK1/2/FoxO1 and AP-1 Pathways in Human Pulmonary Alveolar Epithelial Cells Leads to Up-Regulation of COX-2/PGE(2) Induced by Silica Nanoparticles

The risk of lung exposure to silica nanoparticles (SiNPs) and related lung inflammatory injury is increasing with the wide application of SiNPs in a variety of industries. A growing body of research has revealed that cyclooxygenase (COX)-2/prostaglandin E(2) (PGE(2)) up-regulated by SiNP toxicity ha...

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Detalles Bibliográficos
Autores principales: Lin, Yan-Jyun, Yang, Chien-Chung, Lee, I-Ta, Wu, Wen-Bin, Lin, Chih-Chung, Hsiao, Li-Der, Yang, Chuen-Mao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604097/
https://www.ncbi.nlm.nih.gov/pubmed/37893002
http://dx.doi.org/10.3390/biomedicines11102628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604097/
https://www.ncbi.nlm.nih.gov/pubmed/37893002
http://dx.doi.org/10.3390/biomedicines11102628

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