Genetic and Pharmacological Blockade of Sigma-1 Receptors Attenuates Inflammation-Associated Hypersensitivity during Acute Colitis in CD1 Mice

Sigma-1 receptors (σ(1)Rs) are implicated in nociception, including pain sensitization, and inflammation. We assessed the role of σ(1)Rs on acute colitis-associated hypersensitivity using both genetic (constitutive knockout) and pharmacological blockade of the receptor. Colitis was induced in CD1 wi...

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Detalles Bibliográficos
Autores principales: López-Estévez, Sergio, Aguilera, Mònica, Gris, Georgia, de la Puente, Beatriz, Carceller, Alicia, Martínez, Vicente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604167/
https://www.ncbi.nlm.nih.gov/pubmed/37893131
http://dx.doi.org/10.3390/biomedicines11102758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604167/
https://www.ncbi.nlm.nih.gov/pubmed/37893131
http://dx.doi.org/10.3390/biomedicines11102758

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