In Vitro and In Vivo Chaperone Effect of (R)-2-amino-6-(1R, 2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropterin-4(3H)-one on the C1473G Mutant Tryptophan Hydroxylase 2

Tryptophan hydroxylase 2 (TPH2) is the key and rate-limiting enzyme of serotonin (5-HT) synthesis in the mammalian brain. The 1473G mutation in the Tph2 gene decreases TPH2 activity in the mouse brain by twofold. (R)-2-amino-6-(1R, 2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropterin-4(3H)-one (BH(4))...

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Detalles Bibliográficos
Autores principales: Arefieva, Alla B., Komleva, Polina D., Naumenko, Vladimir S., Khotskin, Nikita V., Kulikov, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604173/
https://www.ncbi.nlm.nih.gov/pubmed/37892138
http://dx.doi.org/10.3390/biom13101458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604173/
https://www.ncbi.nlm.nih.gov/pubmed/37892138
http://dx.doi.org/10.3390/biom13101458

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