Melatonin-Mediated Suppression of mtROS-JNK-FOXO1 Pathway Alleviates Hypoxia-Induced Apoptosis in Porcine Granulosa Cells

Numerous studies have established that the hypoxic conditions within ovarian follicles induce apoptosis in granulosa cells (GCs), a pivotal hallmark of follicular atresia. Melatonin (N-acetyl-5-methoxytryptamine, MT), a versatile antioxidant naturally present in follicular fluid, acts as a safeguard...

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Detalles Bibliográficos
Autores principales: Zhang, Xuan, Zhang, Dingding, Li, Hongmin, Liu, Zhaojun, Yang, Yatong, Li, Jiameng, Tang, Lishiyuan, Tao, Jingli, Liu, Honglin, Shen, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604184/
https://www.ncbi.nlm.nih.gov/pubmed/37891959
http://dx.doi.org/10.3390/antiox12101881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604184/
https://www.ncbi.nlm.nih.gov/pubmed/37891959
http://dx.doi.org/10.3390/antiox12101881

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