Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice

GCN2 is one of the main sensors of amino acid starvation stress, and its activation in the stressful tumor microenvironment plays a crucial role in tumor survival and progression. We hypothesized that elevated polyamine biosynthesis and subsequent depletion of precursor arginine activates GCN2, thus...

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Detalles Bibliográficos
Autores principales: Alexander, Eric T., Fahey, Erin, Phanstiel, Otto, Gilmour, Susan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604246/
https://www.ncbi.nlm.nih.gov/pubmed/37893077
http://dx.doi.org/10.3390/biomedicines11102703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604246/
https://www.ncbi.nlm.nih.gov/pubmed/37893077
http://dx.doi.org/10.3390/biomedicines11102703

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