Highly Selective MIF Ketonase Inhibitor KRP-6 Diminishes M1 Macrophage Polarization and Metabolic Reprogramming

Macrophage polarization is highly involved in autoimmunity. M1 polarized macrophages drive inflammation and undergo metabolic reprogramming, involving downregulation of mitochondrial energy production and acceleration of glycolysis. Macrophage migration inhibitory factor (MIF), an enigmatic tautomer...

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Detalles Bibliográficos
Autores principales: Vámos, Eszter, Kálmán, Nikoletta, Sturm, Eva Maria, Nayak, Barsha Baisakhi, Teppan, Julia, Vántus, Viola Bagóné, Kovács, Dominika, Makszin, Lilla, Loránd, Tamás, Gallyas, Ferenc, Radnai, Balázs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604361/
https://www.ncbi.nlm.nih.gov/pubmed/37891870
http://dx.doi.org/10.3390/antiox12101790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604361/
https://www.ncbi.nlm.nih.gov/pubmed/37891870
http://dx.doi.org/10.3390/antiox12101790

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