Extra-Synaptic GABA(A) Receptor Potentiation and Neurosteroid-Induced Learning Deficits Are Inhibited by GR3027, a GABA(A) Modulating Steroid Antagonist

Objectives In Vitro: To study the effects of GR3027 (golexanolone) on neurosteroid-induced GABA-mediated current responses under physiological GABAergic conditions with recombinant human α5β3γ2L and α1β2γ2L GABA(A) receptors expressed in human embryonic kidney cells, using the response patch clamp t...

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Detalles Bibliográficos
Autores principales: Bengtsson, Sara K. S., Sjöstedt, Jessica, Malinina, Evgenya, Das, Roshni, Doverskog, Magnus, Johansson, Maja, Haage, David, Bäckström, Torbjörn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604444/
https://www.ncbi.nlm.nih.gov/pubmed/37892178
http://dx.doi.org/10.3390/biom13101496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604444/
https://www.ncbi.nlm.nih.gov/pubmed/37892178
http://dx.doi.org/10.3390/biom13101496

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