Stable Isotope-Assisted Untargeted Metabolomics Identifies ALDH1A1-Driven Erythronate Accumulation in Lung Cancer Cells

Using an untargeted stable isotope-assisted metabolomics approach, we identify erythronate as a metabolite that accumulates in several human cancer cell lines. Erythronate has been reported to be a detoxification product derived from off-target glycolytic metabolism. We use chemical inhibitors and g...

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Detalles Bibliográficos
Autores principales: Zhang, Jie, Keibler, Mark A., Dong, Wentao, Ghelfi, Jenny, Cordes, Thekla, Kanashova, Tamara, Pailot, Arnaud, Linster, Carole L., Dittmar, Gunnar, Metallo, Christian M., Lautenschlaeger, Tim, Hiller, Karsten, Stephanopoulos, Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604529/
https://www.ncbi.nlm.nih.gov/pubmed/37893215
http://dx.doi.org/10.3390/biomedicines11102842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604529/
https://www.ncbi.nlm.nih.gov/pubmed/37893215
http://dx.doi.org/10.3390/biomedicines11102842

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