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CRTC2 activates the epithelial–mesenchymal transition of diabetic kidney disease through the CREB-Smad2/3 pathway

BACKGROUND: Epithelial–mesenchymal transition (EMT) plays a key role in tubulointerstitial fibrosis, which is a hallmark of diabetic kidney disease (DKD). Our previous studies showed that CRTC2 can simultaneously regulate glucose metabolism and lipid metabolism. However, it is still unclear whether...

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Detalles Bibliográficos
Autores principales: Li, Yujie, Zhang, Yufeng, Shi, Hongshuo, Liu, Xuemei, Li, Zifa, Zhang, Jiayi, Wang, Xiuge, Wang, Wenbo, Tong, Xiaolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604535/
https://www.ncbi.nlm.nih.gov/pubmed/37884902
http://dx.doi.org/10.1186/s10020-023-00744-0