Downregulation of fibromodulin attenuates inflammatory signaling and atrial fibrosis in spontaneously hypertensive rats with atrial fibrillation via inhibiting TLR4/NLRP3 signaling pathway

BACKGROUND: Myocardial fibrosis is an important factor in the induction and maintenance of atrial fibrillation (AF). Fibromodulin (FMOD) promotes fibrotic gene expression. However, its specific role in spontaneously hypertensive rats (SHR)‐AF remains unclear. METHODS: We analyzed FMOD mRNA and prote...

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Detalles Bibliográficos
Autores principales: Liang, Yuming, Zhou, Yun, Wang, Jialin, He, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604567/
https://www.ncbi.nlm.nih.gov/pubmed/37904680
http://dx.doi.org/10.1002/iid3.1003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604567/
https://www.ncbi.nlm.nih.gov/pubmed/37904680
http://dx.doi.org/10.1002/iid3.1003

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