Monocarboxylate Transporter-1 (MCT1)-Mediated Lactate Uptake Protects Pancreatic Adenocarcinoma Cells from Oxidative Stress during Glutamine Scarcity Thereby Promoting Resistance against Inhibitors of Glutamine Metabolism

Metabolic compartmentalization of stroma-rich tumors, like pancreatic ductal adenocarcinoma (PDAC), greatly contributes to malignancy. This involves cancer cells importing lactate from the microenvironment (reverse Warburg cells) through monocarboxylate transporter-1 (MCT1) along with substantial ph...

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Detalles Bibliográficos
Autores principales: Ammar, Nourhane, Hildebrandt, Maya, Geismann, Claudia, Röder, Christian, Gemoll, Timo, Sebens, Susanne, Trauzold, Ania, Schäfer, Heiner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604597/
https://www.ncbi.nlm.nih.gov/pubmed/37891897
http://dx.doi.org/10.3390/antiox12101818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604597/
https://www.ncbi.nlm.nih.gov/pubmed/37891897
http://dx.doi.org/10.3390/antiox12101818

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