An Induced Pluripotent Stem Cell-Derived Human Blood–Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides

The blood–brain barrier (BBB) is the specialised microvasculature system that shields the central nervous system (CNS) from potentially toxic agents. Attempts to develop therapeutic agents targeting the CNS have been hindered by the lack of predictive models of BBB crossing. In vitro models mimickin...

Descripción completa

Detalles Bibliográficos
Autores principales: Selvakumaran, Jamuna, Ursu, Simona, Bowerman, Melissa, Lu-Nguyen, Ngoc, Wood, Matthew J., Malerba, Alberto, Yáñez-Muñoz, Rafael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604610/
https://www.ncbi.nlm.nih.gov/pubmed/37893074
http://dx.doi.org/10.3390/biomedicines11102700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604610/
https://www.ncbi.nlm.nih.gov/pubmed/37893074
http://dx.doi.org/10.3390/biomedicines11102700

Ejemplares similares