Glycine-Alanine Dipeptide Repeat Protein from C9-ALS Interacts with Sulfide Quinone Oxidoreductase (SQOR) to Induce the Activity of the NLRP3 Inflammasome in HMC3 Microglia: Irisflorentin Reverses This Interaction

Amyotrophic lateral sclerosis (ALS) is a fatal rare disease of progressive degeneration of motor neurons. The most common genetic mutation in ALS is the hexanucleotide repeat expansion (HRE) located in the first intron of the C9orf72 gene (C9-ALS). HRE can produce dipeptide repeat proteins (DPRs) su...

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Detalles Bibliográficos
Autores principales: Fu, Ru-Huei, Chen, Hui-Jye, Hong, Syuan-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604625/
https://www.ncbi.nlm.nih.gov/pubmed/37891975
http://dx.doi.org/10.3390/antiox12101896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604625/
https://www.ncbi.nlm.nih.gov/pubmed/37891975
http://dx.doi.org/10.3390/antiox12101896

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