Unraveling the Mechanism of Epichaperome Modulation by Zelavespib: Biochemical Insights on Target Occupancy and Extended Residence Time at the Site of Action

Drugs with a long residence time at their target sites are often more efficacious in disease treatment. The mechanism, however, behind prolonged retention at the site of action is often difficult to understand for non-covalent agents. In this context, we focus on epichaperome agents, such as zelaves...

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Detalles Bibliográficos
Autores principales: Sharma, Sahil, Joshi, Suhasini, Kalidindi, Teja, Digwal, Chander S., Panchal, Palak, Lee, Sang-Gyu, Zanzonico, Pat, Pillarsetty, Nagavarakishore, Chiosis, Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604720/
https://www.ncbi.nlm.nih.gov/pubmed/37892973
http://dx.doi.org/10.3390/biomedicines11102599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604720/
https://www.ncbi.nlm.nih.gov/pubmed/37892973
http://dx.doi.org/10.3390/biomedicines11102599

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