Caffeine-folic acid-loaded-chitosan nanoparticles combined with methotrexate as a novel HepG2 immunotherapy targeting adenosine A2A receptor downstream cascade

BACKGROUND: Methotrexate (MTX) is a common chemotherapeutic drug that inhibits DNA synthesis and induces apoptosis. Treatment with MTX increased CD73 expression, which leads to higher levels of extracellular adenosine. Adenosine levels are also high in the tumor microenvironment through Cancer cells...

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Detalles Bibliográficos
Autores principales: Hamed, Alaa, Ghareeb, Doaa, Mohamed, Tarek M., Hamed, Mahmoud, Nofal, Mohammed S., Gaber, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604858/
https://www.ncbi.nlm.nih.gov/pubmed/37891562
http://dx.doi.org/10.1186/s12906-023-04212-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604858/
https://www.ncbi.nlm.nih.gov/pubmed/37891562
http://dx.doi.org/10.1186/s12906-023-04212-4

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