The Insulin-Degrading Enzyme from Structure to Allosteric Modulation: New Perspectives for Drug Design

The insulin-degrading enzyme (IDE) is a Zn(2+) peptidase originally discovered as the main enzyme involved in the degradation of insulin and other amyloidogenic peptides, such as the β-amyloid (Aβ) peptide. Therefore, a role for the IDE in the cure of diabetes and Alzheimer’s disease (AD) has been l...

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Detalles Bibliográficos
Autores principales: Tundo, Grazia Raffaella, Grasso, Giuseppe, Persico, Marco, Tkachuk, Oleh, Bellia, Francesco, Bocedi, Alessio, Marini, Stefano, Parravano, Mariacristina, Graziani, Grazia, Fattorusso, Caterina, Sbardella, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604886/
https://www.ncbi.nlm.nih.gov/pubmed/37892174
http://dx.doi.org/10.3390/biom13101492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604886/
https://www.ncbi.nlm.nih.gov/pubmed/37892174
http://dx.doi.org/10.3390/biom13101492

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