Targeting GD2-Positive Tumor Cells by Pegylated scFv Fragment–Drug Conjugates Carrying Maytansinoids DM1 and DM4

Oligomerization of antibody fragments via modification with polyethylene glycol (pegylation) may alter their function and properties, leading to a multivalent interaction of the resulting constructs with the target antigen. In a recent study, we generated pegylated monomers and multimers of scFv fra...

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Detalles Bibliográficos
Autores principales: Kalinovsky, Daniel V., Kholodenko, Irina V., Svirshchevskaya, Elena V., Kibardin, Alexey V., Ryazantsev, Dmitry Yu., Rozov, Fedor N., Larin, Sergey S., Deyev, Sergey M., Kholodenko, Roman V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604934/
https://www.ncbi.nlm.nih.gov/pubmed/37886955
http://dx.doi.org/10.3390/cimb45100512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604934/
https://www.ncbi.nlm.nih.gov/pubmed/37886955
http://dx.doi.org/10.3390/cimb45100512

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