lncRNA Sequencing Reveals Neurodegeneration-Associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists in Motor Neurons

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Fused-in sarcoma (FUS) gene mutations have been implicated in amyotrophic lateral sclerosis (ALS). This study aimed to investigate the impact of FUS mutations (R521H and P525L) on the transcriptome of induced pluripotent stem cells (iPSCs) and iPSC-derived motor neurons (iMNs). Using RNA sequencing...

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Detalles Bibliográficos
Autores principales: Provasek, Vincent E., Kodavati, Manohar, Guo, Wenting, Wang, Haibo, Boldogh, Istvan, Van Den Bosch, Ludo, Britz, Gavin, Hegde, Muralidhar L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604943/
https://www.ncbi.nlm.nih.gov/pubmed/37887305
http://dx.doi.org/10.3390/cells12202461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604943/
https://www.ncbi.nlm.nih.gov/pubmed/37887305
http://dx.doi.org/10.3390/cells12202461

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