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lncRNA Sequencing Reveals Neurodegeneration-Associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists in Motor Neurons
Fused-in sarcoma (FUS) gene mutations have been implicated in amyotrophic lateral sclerosis (ALS). This study aimed to investigate the impact of FUS mutations (R521H and P525L) on the transcriptome of induced pluripotent stem cells (iPSCs) and iPSC-derived motor neurons (iMNs). Using RNA sequencing...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604943/ https://www.ncbi.nlm.nih.gov/pubmed/37887305 http://dx.doi.org/10.3390/cells12202461 |
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por Provasek, Vincent E., Kodavati, Manohar, Guo, Wenting, Wang, Haibo, Boldogh, Istvan, Van Den Bosch, Ludo, Britz, Gavin, Hegde, Muralidhar
Publicado 2023
Enlace del recurso
Publicado 2023
Enlace del recurso
Enlace del recurso
Online
Artículo
Texto