RNA structure and multiple weak interactions balance the interplay between RNA binding and phase separation of SARS-CoV-2 nucleocapsid

The nucleocapsid (N) protein of SARS-CoV-2 binds viral RNA, condensing it inside the virion, and phase separating with RNA to form liquid–liquid condensates. There is little consensus on what differentiates sequence-independent N–RNA interactions in the virion or in liquid droplets from those with s...

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Detalles Bibliográficos
Autores principales: Estelle, Aidan B, Forsythe, Heather M, Yu, Zhen, Hughes, Kaitlyn, Lasher, Brittany, Allen, Patrick, Reardon, Patrick N, Hendrix, David A, Barbar, Elisar J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605006/
https://www.ncbi.nlm.nih.gov/pubmed/37901441
http://dx.doi.org/10.1093/pnasnexus/pgad333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605006/
https://www.ncbi.nlm.nih.gov/pubmed/37901441
http://dx.doi.org/10.1093/pnasnexus/pgad333

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