Defucosylated Monoclonal Antibody (H(2)Mab-139-mG(2a)-f) Exerted Antitumor Activities in Mouse Xenograft Models of Breast Cancers against Human Epidermal Growth Factor Receptor 2

The clinically approved human epidermal growth factor receptor 2 (HER2)-targeting monoclonal antibodies (mAbs), trastuzumab, and pertuzumab, target domains IV and II, respectively. Trastuzumab is now the standard treatment for HER2-overexpressed breast and gastric cancers, and trastuzumab in combina...

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Detalles Bibliográficos
Autores principales: Suzuki, Hiroyuki, Ohishi, Tomokazu, Nanamiya, Ren, Kawada, Manabu, Kaneko, Mika K., Kato, Yukinari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605610/
https://www.ncbi.nlm.nih.gov/pubmed/37886932
http://dx.doi.org/10.3390/cimb45100488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605610/
https://www.ncbi.nlm.nih.gov/pubmed/37886932
http://dx.doi.org/10.3390/cimb45100488

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