Double Duty: Complete Pathologic Response of Two Colonic Primaries with Mosaicism of a Novel MLH1 Mutation to Neoadjuvant Pembrolizumab

We present a fascinating case of a 57-year-old male with a novel mutation in MLH1 (MLH1:c.1288G > T, p.(Glu430*)), who presented with two synchronous colonic tumours, initially deemed unresectable, and experienced a complete pathological response on neoadjuvant pembrolizumab. Extensive genetic te...

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Detalles Bibliográficos
Autores principales: Preti, Beatrice, Schenkel, Laila, Cecchini, Matthew, Romagnoli, Tommaso, Sanatani, Michael Susmoy, French, Karissa, Colquhoun, Patrick, Vincent, Mark David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605803/
https://www.ncbi.nlm.nih.gov/pubmed/37887553
http://dx.doi.org/10.3390/curroncol30100653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605803/
https://www.ncbi.nlm.nih.gov/pubmed/37887553
http://dx.doi.org/10.3390/curroncol30100653

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