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Double Duty: Complete Pathologic Response of Two Colonic Primaries with Mosaicism of a Novel MLH1 Mutation to Neoadjuvant Pembrolizumab
We present a fascinating case of a 57-year-old male with a novel mutation in MLH1 (MLH1:c.1288G > T, p.(Glu430*)), who presented with two synchronous colonic tumours, initially deemed unresectable, and experienced a complete pathological response on neoadjuvant pembrolizumab. Extensive genetic te...
Autores principales: | Preti, Beatrice, Schenkel, Laila, Cecchini, Matthew, Romagnoli, Tommaso, Sanatani, Michael Susmoy, French, Karissa, Colquhoun, Patrick, Vincent, Mark David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605803/ https://www.ncbi.nlm.nih.gov/pubmed/37887553 http://dx.doi.org/10.3390/curroncol30100653 |
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