Usnic Acid Derivatives Inhibit DNA Repair Enzymes Tyrosyl-DNA Phosphodiesterases 1 and 2 and Act as Potential Anticancer Agents

Tyrosyl-DNA phosphodiesterase 1 and 2 (Tdp1 and Tdp2) are DNA repair enzymes that repair DNA damage caused by various agents, including anticancer drugs. Thus, these enzymes resist anticancer therapy and could be the reason for resistance to such widely used drugs such as topotecan and etoposide. In...

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Detalles Bibliográficos
Autores principales: Zakharenko, Alexandra L., Dyrkheeva, Nadezhda S., Luzina, Olga A., Filimonov, Aleksandr S., Mozhaitsev, Evgenii S., Malakhova, Anastasia A., Medvedev, Sergey P., Zakian, Suren M., Salakhutdinov, Nariman F., Lavrik, Olga I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606488/
https://www.ncbi.nlm.nih.gov/pubmed/37895279
http://dx.doi.org/10.3390/genes14101931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606488/
https://www.ncbi.nlm.nih.gov/pubmed/37895279
http://dx.doi.org/10.3390/genes14101931

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