Effects of Mithramycin on BCL11A Gene Expression and on the Interaction of the BCL11A Transcriptional Complex to γ-Globin Gene Promoter Sequences

The anticancer drug mithramycin (MTH), has been proposed for drug repurposing after the finding that it is a potent inducer of fetal hemoglobin (HbF) production in erythroid precursor cells (ErPCs) from β-thalassemia patients. In this respect, previously published studies indicate that MTH is very a...

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Detalles Bibliográficos
Autores principales: Finotti, Alessia, Gasparello, Jessica, Zuccato, Cristina, Cosenza, Lucia Carmela, Fabbri, Enrica, Bianchi, Nicoletta, Gambari, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606601/
https://www.ncbi.nlm.nih.gov/pubmed/37895276
http://dx.doi.org/10.3390/genes14101927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606601/
https://www.ncbi.nlm.nih.gov/pubmed/37895276
http://dx.doi.org/10.3390/genes14101927

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