Decrease in α-Globin and Increase in the Autophagy-Activating Kinase ULK1 mRNA in Erythroid Precursors from β-Thalassemia Patients Treated with Sirolimus

The β-thalassemias are hereditary monogenic diseases characterized by a low or absent production of adult hemoglobin and excess in the content of α-globin. This excess is cytotoxic for the erythroid cells and responsible for the β-thalassemia-associated ineffective erythropoiesis. Therefore, the dec...

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Detalles Bibliográficos
Autores principales: Zurlo, Matteo, Zuccato, Cristina, Cosenza, Lucia Carmela, Gasparello, Jessica, Gamberini, Maria Rita, Stievano, Alice, Fortini, Monica, Prosdocimi, Marco, Finotti, Alessia, Gambari, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606773/
https://www.ncbi.nlm.nih.gov/pubmed/37894732
http://dx.doi.org/10.3390/ijms242015049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606773/
https://www.ncbi.nlm.nih.gov/pubmed/37894732
http://dx.doi.org/10.3390/ijms242015049

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