Thrombin-Induced COX-2 Expression and PGE(2) Synthesis in Human Tracheal Smooth Muscle Cells: Role of PKCδ/Pyk2-Dependent AP-1 Pathway Modulation

In this study, we confirmed that thrombin significantly increases the production of COX-2 and PGE(2) in human tracheal smooth muscle cells (HTSMCs), leading to inflammation in the airways and lungs. These molecules are well-known contributors to various inflammatory diseases. Here, we investigated i...

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Detalles Bibliográficos
Autores principales: Yang, Chien-Chung, Lee, I-Ta, Lin, Yan-Jyun, Wu, Wen-Bin, Hsiao, Li-Der, Yang, Chuen-Mao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606820/
https://www.ncbi.nlm.nih.gov/pubmed/37894811
http://dx.doi.org/10.3390/ijms242015130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606820/
https://www.ncbi.nlm.nih.gov/pubmed/37894811
http://dx.doi.org/10.3390/ijms242015130

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