Interactions of Nucleosomes with Acidic Patch-Binding Peptides: A Combined Structural Bioinformatics, Molecular Modeling, Fluorescence Polarization, and Single-Molecule FRET Study

In eukaryotic organisms, genomic DNA associates with histone proteins to form nucleosomes. Nucleosomes provide a basis for genome compaction, epigenetic markup, and mediate interactions of nuclear proteins with their target DNA loci. A negatively charged (acidic) patch located on the H2A-H2B histone...

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Detalles Bibliográficos
Autores principales: Oleinikov, Pavel D., Fedulova, Anastasiia S., Armeev, Grigoriy A., Motorin, Nikita A., Singh-Palchevskaia, Lovepreet, Sivkina, Anastasiia L., Feskin, Pavel G., Glukhov, Grigory S., Afonin, Dmitry A., Komarova, Galina A., Kirpichnikov, Mikhail P., Studitsky, Vasily M., Feofanov, Alexey V., Shaytan, Alexey K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606924/
https://www.ncbi.nlm.nih.gov/pubmed/37894874
http://dx.doi.org/10.3390/ijms242015194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606924/
https://www.ncbi.nlm.nih.gov/pubmed/37894874
http://dx.doi.org/10.3390/ijms242015194

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