Cargando…

Small Molecule Pytren-4QMn Metal Complex Slows down Huntington’s Disease Progression in Male zQ175 Transgenic Mice

Huntington’s disease (HD) is an inherited neurodegenerative disorder considered a rare disease with a prevalence of 5.7 per 100,000 people. It is caused by an autosomal dominant mutation consisting of expansions of trinucleotide repeats that translate into poly-glutamine enlarged mutant huntingtin p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Merino, Marián, González, Sonia, Tronch, Mª Carmen, Sánchez-Sánchez, Ana Virginia, Clares, Mª Paz, García-España, Antonio, García-España, Enrique, Mullor, José L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607077/ https://www.ncbi.nlm.nih.gov/pubmed/37894844 http://dx.doi.org/10.3390/ijms242015153

Ejemplares similares

Mn(II) Quinoline Complex (4QMn) Restores Proteostasis and Reduces Toxicity in Experimental Models of Huntington’s Disease
por: Merino, Marián, et al.
Publicado: (2022)

Significant In Vivo Anti-Inflammatory Activity of Pytren4Q-Mn a Superoxide Dismutase 2 (SOD2) Mimetic Scorpiand-Like Mn (II) Complex
por: Serena, Carolina, et al.
Publicado: (2015)

Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease
por: Sanchis, Ana, et al.
Publicado: (2019)

Abnormal Brain Development in Huntington’ Disease Is Recapitulated in the zQ175 Knock-In Mouse Model
por: Zhang, Chuangchuang, et al.
Publicado: (2020)

Enhanced GABAergic Inhibition of Cholinergic Interneurons in the zQ175(+/−) Mouse Model of Huntington's Disease
por: Lim, Sean Austin O., et al.
Publicado: (2021)

The Urine Metabolome of R6/2 and zQ175DN Huntington’s Disease Mouse Models
por: Speziale, Roberto, et al.
Publicado: (2023)

Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175
por: Menalled, Liliana B., et al.
Publicado: (2012)

Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington’s Disease
por: Peng, Qi, et al.
Publicado: (2016)

Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington’s Disease Knock-in Mice
por: Schindler, Franziska, et al.
Publicado: (2021)

Optimising Golgi–Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease
por: Bayram-Weston, Zubeyde, et al.
Publicado: (2016)

Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease
por: Heikkinen, Taneli, et al.
Publicado: (2012)

Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study
por: Carty, Nikisha, et al.
Publicado: (2015)

Metabotropic Glutamate Receptor 5 Antagonism Reduces Pathology and Differentially Improves Symptoms in Male and Female Heterozygous zQ175 Huntington’s Mice
por: Li, Si Han, et al.
Publicado: (2022)

Longitudinal investigation of changes in resting-state co-activation patterns and their predictive ability in the zQ175 DN mouse model of Huntington’s disease
por: Adhikari, Mohit H., et al.
Publicado: (2023)

Genetic Deletion of Transglutaminase 2 Does Not Rescue the Phenotypic Deficits Observed in R6/2 and zQ175 Mouse Models of Huntington's Disease
por: Menalled, Liliana B., et al.
Publicado: (2014)

Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ175 mice
por: Abd-Elrahman, Khaled S., et al.
Publicado: (2019)

A mixed fixed ratio/progressive ratio procedure reveals an apathy phenotype in the BAC HD and the z_Q175 KI mouse models of Huntington’s disease
por: Oakeshott, Stephen, et al.
Publicado: (2012)

Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD
por: Curtin, Paul C. P., et al.
Publicado: (2016)

Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches
por: Smith, Edward J, et al.
Publicado: (2023)

The Embryonic Key Pluripotent Factor NANOG Mediates Glioblastoma Cell Migration via the SDF1/CXCR4 Pathway
por: Sánchez-Sánchez, Ana Virginia, et al.
Publicado: (2021)

Improved synthesis of [(18)F] fallypride and characterization of a Huntington’s disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2/D3 receptors
por: Huhtala, Tuulia, et al.
Publicado: (2019)

Cell-Type Specific Regulation of Cholesterogenesis by CYP46A1 Re-Expression in zQ175 HD Mouse Striatum
por: Pinchaud, Katleen, et al.
Publicado: (2023)

Search for t to Zq
por: CMS Collaboration
Publicado: (2012)

Extensive Expression Analysis of Htt Transcripts in Brain Regions from the zQ175 HD Mouse Model Using a QuantiGene Multiplex Assay
por: Papadopoulou, Aikaterini S., et al.
Publicado: (2019)

Neurocardiovascular deficits in the Q175 mouse model of Huntington's disease
por: Cutler, Tamara S., et al.
Publicado: (2017)

Global Rhes knockout in the Q175 Huntington’s disease mouse model
por: Heikkinen, Taneli, et al.
Publicado: (2021)

A Metal-Based Receptor for Selective Coordination and Fluorescent Sensing of Chloride
por: Formica, Mauro, et al.
Publicado: (2021)

Medaka (Oryzias latipes) Embryo as a Model for the Screening of Compounds that Counteract the Damage Induced by Ultraviolet and High-Energy Visible Light
por: Merino, Marián, et al.
Publicado: (2020)

Cholinergic Interneurons Amplify Corticostriatal Synaptic Responses in the Q175 Model of Huntington’s Disease
por: Tanimura, Asami, et al.
Publicado: (2016)

Progression of basal ganglia pathology in heterozygous Q175 knock‐in Huntington's disease mice
por: Deng, Yunping, et al.
Publicado: (2020)

Comparison of Huntington’s disease phenotype progression in male and female heterozygous FDNQ175 mice
por: Li, Si Han, et al.
Publicado: (2023)

The Bioactivity of Xylene, Pyridine, and Pyrazole Aza Macrocycles against Three Representative Leishmania Species †
por: Martín-Montes, Álvaro, et al.
Publicado: (2023)

Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington’s Disease Mouse Striatum
por: Iuliano, Maria, et al.
Publicado: (2021)

Study of ATLAS Sensitivity to FCNC TOP Quark Decay $t \to Zq$
por: Chikovani, Leila, et al.
Publicado: (2000)

ATLAS Sensitivity to the Flavour-Changing Neutral Current Decay $t \to Zq$
por: Chikovani, Leila, et al.
Publicado: (2002)

Analysis of the Ush2a Gene in Medaka Fish (Oryzias latipes)
por: Aller, Elena, et al.
Publicado: (2013)

Dylan Cooper Frizzell - Top2019 YSF - tZq Observation
por: Frizzell, Dylan Cooper
Publicado: (2019)

ATLAS Experiment Sensitivity to the Flavor-Changing Neutral Currents Decay t--> Zq
por: Chikovani, L D, et al.
Publicado: (1999)

Highlights of tt , tZq and ttγ production measurements at ATLAS
por: Fabbri, Federica
Publicado: (2020)

Probing the physical properties for prospective high energy applications of QMnF(3) (Q = Ga, In) halide perovskites compounds employing the framework of density functional theory
por: Tahir, Fareesa Tasneem, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_s6uuluhmqugkq27u9r315ptatq