AZD-7648, a DNA-PK Inhibitor, Induces DNA Damage, Apoptosis, and Cell Cycle Arrest in Chronic and Acute Myeloid Leukemia Cells

The non-homologous end joining pathway is vital for repairing DNA double-strand breaks (DSB), with DNA-dependent protein kinase (DNA-PK) playing a critical role. Altered DNA damage response (DDR) in chronic (CML) and acute myeloid leukemia (AML) offers potential therapeutic opportunities. We studied...

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Detalles Bibliográficos
Autores principales: Lapa, Beatriz Santos, Costa, Maria Inês, Figueiredo, Diana, Jorge, Joana, Alves, Raquel, Monteiro, Ana Raquel, Serambeque, Beatriz, Laranjo, Mafalda, Botelho, Maria Filomena, Carreira, Isabel Marques, Sarmento-Ribeiro, Ana Bela, Gonçalves, Ana Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607085/
https://www.ncbi.nlm.nih.gov/pubmed/37895013
http://dx.doi.org/10.3390/ijms242015331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607085/
https://www.ncbi.nlm.nih.gov/pubmed/37895013
http://dx.doi.org/10.3390/ijms242015331

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