miR-632 Induces DNAJB6 Inhibition Stimulating Endothelial-to-Mesenchymal Transition and Fibrosis in Marfan Syndrome Aortopathy

Marfan syndrome (MFS) is a connective tissue disorder caused by FBN1 gene mutations leading to TGF-β signaling hyperactivation, vascular wall weakness, and thoracic aortic aneurysms (TAAs). The pathogenetic mechanisms are not completely understood and patients undergo early vascular surgery to preve...

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Detalles Bibliográficos
Autores principales: Terriaca, Sonia, Scioli, Maria Giovanna, Pisano, Calogera, Ruvolo, Giovanni, Ferlosio, Amedeo, Orlandi, Augusto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607153/
https://www.ncbi.nlm.nih.gov/pubmed/37894814
http://dx.doi.org/10.3390/ijms242015133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607153/
https://www.ncbi.nlm.nih.gov/pubmed/37894814
http://dx.doi.org/10.3390/ijms242015133

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