New Flexible Analogues of 8-Aza-7-deazapurine Nucleosides as Potential Antibacterial Agents

A variety of ribo-, 2′-deoxyribo-, and 5′-norcarbocyclic derivatives of the 8-aza-7-deazahypoxanthine fleximer scaffolds were designed, synthesized, and screened for antibacterial activity. Both chemical and chemoenzymatic methods of synthesis for the 8-aza-7-deazainosine fleximers were compared. In...

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Detalles Bibliográficos
Autores principales: Khandazhinskaya, Anastasia, Eletskaya, Barbara, Mironov, Anton, Konstantinova, Irina, Efremenkova, Olga, Andreevskaya, Sofya, Smirnova, Tatiana, Chernousova, Larisa, Kondrashova, Evgenia, Chizhov, Alexander, Seley-Radtke, Katherine, Kochetkov, Sergey, Matyugina, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607158/
https://www.ncbi.nlm.nih.gov/pubmed/37895100
http://dx.doi.org/10.3390/ijms242015421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607158/
https://www.ncbi.nlm.nih.gov/pubmed/37895100
http://dx.doi.org/10.3390/ijms242015421

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